What is the function of Granulysin in the immune system?

What is the function of Granulysin in the immune system?

• A. Inhibits cytokine production
• B. Forms holes in microbial cell membranes
• C. Stimulates the production of antibodies
• D. Enhances phagocytic activity

Answer: (B)

Granulysin plays a crucial role in the immune system, particularly in the response to infections caused by bacteria and viruses. Its primary function is to form pores in the cell membranes of these pathogens. By creating holes in the microbial cell membranes, granulysin disrupts the integrity of the cells, leading to the destruction of the pathogens. This action is part of the mechanism by which cytotoxic T lymphocytes and natural killer (NK) cells eliminate infected or malignant cells. The ability to induce cell lysis is vital for effectively controlling infections and preventing their spread within the body. This demonstrates granulysin's importance in the innate immune response and its role in defending the body against various microbial threats.